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HomeProduct name listTeneligliptin

Teneligliptin

Teneligliptin Structural

What is Teneligliptin?

Description

Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).

Originator

Mitsubishi Tanabe Pharma (Japan)

The Uses of Teneligliptin

Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Definition

ChEBI: Teneligliptin is an amino acid amide.

brand name

Tenelia

Properties of Teneligliptin

Melting point: >100°C (dec.)
Boiling point: 663.4±55.0 °C(Predicted)
Density  1.38
storage temp.  Refrigerator
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 8.70±0.10(Predicted)
color  Off-White

Safety information for Teneligliptin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P362:Take off contaminated clothing and wash before reuse.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Teneligliptin

Abamectin manufacturer

Prayosha Health Care Pvt Ltd

1Y
Phone:+91-9924448881
Whatsapp: +91 9924448881
product: Teneligliptin 99%
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Glenmark Pharmaceuticals Limited

1Y
Phone:+912240189999
product: Teneligliptin 760937-92-6 98%
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Venture Pharmaceuticals pvt ltd

1Y
Phone:+91-9173909075
Whatsapp: +91-9173909075
product: 760937-92-6 Teneligliptin 98%
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Smruthi Organics Limited

1Y
Phone:+91-9822910599
Whatsapp: +91- 9822910599
product: 760937-92-6 98%
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Unichem Laboratories Ltd

1Y
Phone:+91-2266888333
product: Teneligliptin 98%
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Excel Industries Limited

1Y
Phone:+91-2266464200
Whatsapp: 91-22-66464200
product: Teneligliptin 760937-92-6 99%
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Alcove International

1Y
Phone:+91-9998996552
Whatsapp: +91 9998996552
product: 760937-92-6 Teneligliptin 98%
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Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: 760937-92-6 98%
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Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Teneligliptin 98%
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