Teneligliptin
- CAS NO.:760937-92-6
- Empirical Formula: C22H30N6OS
- Molecular Weight: 426.58
- MDL number: MFCD13195565
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is Teneligliptin?
Description
Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).
Originator
Mitsubishi Tanabe Pharma (Japan)
The Uses of Teneligliptin
Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
Definition
ChEBI: Teneligliptin is an amino acid amide.
brand name
Tenelia
Properties of Teneligliptin
Melting point: | >100°C (dec.) |
Boiling point: | 663.4±55.0 °C(Predicted) |
Density | 1.38 |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 8.70±0.10(Predicted) |
color | Off-White |
Safety information for Teneligliptin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Teneligliptin
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Prayosha Health Care Pvt Ltd
Venture Pharmaceuticals pvt ltd
Excel Industries Limited
Alcove International
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