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HomeProduct name listTAPS

TAPS

Synonym(s):[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-1-propanesulfonic acid;N-[Tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid;TAPS

  • CAS NO.:29915-38-6
  • Empirical Formula: C7H17NO6S
  • Molecular Weight: 243.28
  • MDL number: MFCD00007538
  • EINECS: 249-954-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
TAPS Structural

What is TAPS?

Description

TAPS is a zwitterionic buffering agent used in biochemistry and molecular biology. It is part of the Tris family of buffers and is useful for a pH range of 7.7 – 9.1. The members of TRIS family are tris(hydroxymethyl)aminomethane (TRIS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid (TAPS), N-[tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid (TAPSO), and N-tris(hydroxymethyl)methyl-4-aminobutanesulfonic acid (TABS) buffers[1]. The solubilities of TAPS in aqueous solution decrease with increasing concentration of the salts (salting-out effect)[2]. TAPS is the preferred culture media buffer used for dinoflagellate experiments, allowing for minimal pH change and maximal growth. It is also often used in capillary electrophoresis to analyze DNA and in planar chromatography to separate dyes. TAPS may form a complex with some common metals so stability constants and concentrations should be taken into account when choosing this buffer. TAPS is capable of inhibiting connexin channels in animal cells.

Chemical properties

White/clear crystalline powder

The Uses of TAPS

A zwitterionic Good's Buffer

What are the applications of Application

TAPS is a zwitterionic buffer that has a useful pH range of 7.7 - 9.1

Definition

ChEBI: N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid is an organosulfonic acid.

What are the applications of Application

TAPS is a zwitterionic buffer used in biochemistry and molecular biology. It has a useful pH range of 7.7 - 9.1. TAPS has been utilized in capillary electrophoresis of DNA and DNA-dye complexes. Dyes can be separated by planar chromatography with electroosmotic flow containing 1 mM TAPS in the mobile phase. The stability constants of metal ions with TAPS have been investigated through the use of capillary electrophoresis. TAPS has also been shown to inhibit the activity of connexin channels. The activity of various carbonic anhydrases has been studied using TAPS physiological buffer, pKa = 8.4 at 20° C.TAPS

References

[1] Gupta B, et al. Stability Constants for the Equilibrium Models of Iron(III) with Several Biological Buffers in Aqueous Solutions. Journal of Solution Chemistry, 2013; 42: 2296–2309.
[2] Taha M, et al. New Insights into Buffer-Ionic Salt Interactions: Solubilities, Transfer Gibbs Energies, and Transfer Molar Volumes of TAPS and TAPSO from Water to Aqueous Electrolyte Solutions. Journal of Solution Chemistry, 2010; 39: 1665–1680.

Properties of TAPS

Melting point: 230-235 °C (dec.)
Density  1.4290 (rough estimate)
refractive index  1.6370 (estimate)
Flash point: 110 °C
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  H2O: 1 M at 20 °C, clear, colorless
form  Solid
pka 8.55; pKa (37°): 8.1; pKa2 (25°): 8.28
color  White
PH Range 7.7 - 9.1
Odor Odorless
Water Solubility  Soluble
Merck  13,9148
BRN  2452420
Stability: Stable. Incompatible with strong oxidizing agents
CAS DataBase Reference 29915-38-6(CAS DataBase Reference)
EPA Substance Registry System 1-Propanesulfonic acid, 3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (29915-38-6)

Safety information for TAPS

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TAPS

InChIKey YNLCVAQJIKOXER-UHFFFAOYSA-N

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