T0070907
Synonym(s):2-Chloro-5-nitro-N-(4-pyridyl)benzamide;2-Chloro-5-nitro-N-4-pyridinyl-benzamide;Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-;T0070907 - CAS 313516-66-4 - Calbiochem
- CAS NO.:313516-66-4
- Empirical Formula: C12H8ClN3O3
- Molecular Weight: 277.66
- MDL number: MFCD00121849
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is T0070907?
Description
The peroxisome proliferator-
Chemical properties
Off-White Solid
The Uses of T0070907
T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
The Uses of T0070907
A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPAR with a Ki of 1 nM. Displays >800-fold greater selectivity for PPAR over PPARa and PPARd (Ki = 0.85 and 1.8 ,
What are the applications of Application
T0070907 is a cell-permeable chloro-nitro-benzamido compound that acts as a potent and specific antagonist of PPARg
Definition
ChEBI: 2-chloro-5-nitro-N-pyridin-4-ylbenzamide is a carbonyl compound and an organohalogen compound.
General Description
T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
Biological Activity
Potent and selective PPAR γ antagonist (IC 50 = 1 nM). Displays > 800-fold selectivity for PPAR γ over PPAR α and PPAR δ . In vitro, blocks transcriptional activity of PPAR γ and inhibits rosiglitazone-induced adipogenesis.
Biochem/physiol Actions
T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.
storage
Store at RT
References
[1] lee g, elwood f, mcnally j, weiszmann j, lindstrom m, amaral k, nakamura m, miao s, cao p, learned rm, chen jl, li y. t0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. j biol chem. 2002 may 31;277(22):19649-57.
Properties of T0070907
Melting point: | >184°C (dec.) |
Density | 1.498 |
storage temp. | 2-8°C |
solubility | DMSO: >10mg/mL |
form | White solid |
color | white |
Water Solubility | Soluble in DMSO at 10mg/ml. Insoluble in water. |
Sensitive | Light Sensitive |
Safety information for T0070907
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for T0070907
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