Sodium dichloroacetate
Synonym(s):Dichloroacetic acid sodium salt
- CAS NO.：2156-56-1
- Empirical Formula: C2H3Cl2NaO2
- Molecular Weight: 152.93
- MDL number: MFCD00070489
- EINECS: 218-461-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-23 21:30:31
What is Sodium dichloroacetate?
Chemical properties
white powder
The Uses of Sodium dichloroacetate
Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.
The Uses of Sodium dichloroacetate
Treatment of neurologic injury (pyruvate dehydrogenase activator).
What are the applications of Application
Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase
brand name
Ceresine (Cypros).
General Description
Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.
Biological Activity
Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .
Storage
Desiccate at RT
Properties of Sodium dichloroacetate
| Melting point: | 198 °C (dec.) (lit.) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Powder |
| color | White |
| PH | 6.0 to 8.5(50g/L, 25 ℃) |
| Water Solubility | soluble in cold water |
| Sensitive | Moisture Sensitive |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 2156-56-1(CAS DataBase Reference) |
| EPA Substance Registry System | Sodium dichloroacetate (2156-56-1) |
Safety information for Sodium dichloroacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Sodium dichloroacetate
| InChIKey | LUPNKHXLFSSUGS-UHFFFAOYSA-M |
New Products
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