Sodium dichloroacetate

Synonym(s):Dichloroacetic acid sodium salt

CAS NO.：2156-56-1
Empirical Formula: C2H3Cl2NaO2
Molecular Weight: 152.93
MDL number: MFCD00070489
EINECS: 218-461-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is Sodium dichloroacetate?

Chemical properties

white powder

The Uses of Sodium dichloroacetate

Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.

The Uses of Sodium dichloroacetate

Treatment of neurologic injury (pyruvate dehydrogenase activator).

What are the applications of Application

Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase

brand name

Ceresine (Cypros).

General Description

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Biological Activity

Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo .

storage

Desiccate at RT

Properties of Sodium dichloroacetate

Melting point:	198 °C (dec.) (lit.)
storage temp.	Inert atmosphere,2-8°C
solubility	Methanol (Slightly), Water (Slightly)
form	Powder
color	White
PH	6.0 to 8.5(50g/L, 25 ℃)
Water Solubility	soluble in cold water
Sensitive	Moisture Sensitive
Stability:	Hygroscopic
CAS DataBase Reference	2156-56-1(CAS DataBase Reference)
EPA Substance Registry System	Sodium dichloroacetate (2156-56-1)

Safety information for Sodium dichloroacetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.