Seratrodast
- CAS NO.:112665-43-7
- Empirical Formula: C22H26O4
- Molecular Weight: 354.44
- MDL number: MFCD00875701
- EINECS: 692-169-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-14 14:35:52
What is Seratrodast?
Description
Seratrodast, a novel benzoquinone derivative, is the first thromboxane A2 (TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA2 mimic and by a variety of spasmogenic prostanoids including PGF2α, PGD2 and 9α,11β-PGF2. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.
Chemical properties
Pale Orange Solid
Originator
Takeda (Japan)
The Uses of Seratrodast
Thromboxane A2-receptor antagonist. Antiasthmatic.
The Uses of Seratrodast
antibacterial
The Uses of Seratrodast
Thromboxane A2-receptor antagonist. Antiasthmatic
Definition
ChEBI: Seratrodast is an organic molecular entity.
What are the applications of Application
Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist
brand name
Bronica
Biological Activity
Thromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.
in vitro
seratrodast was found to inhibit the aggregation of guinea pig platelets induced by a prostaglandin endoperoxide analogue, u-44069 and the specific binding of another analogue, [3h]u-46619 to washed guinea pig platelets. seratrodast could competitively inhibit the contraction of rabbit aorta and pig coronary arteries induced by u-44069. seratrodast also inhibited the contraction of rabbit aorta induced by pgf2 alpha and the contraction of pig coronary arteries. however, seratrodast had no effect on the antiaggregatory effect of guinea pig platelets [1].
in vivo
in experiments with guinea pigs, oral seratrodast at 0.1-1 mg/kg could dose-dependently inhibit the platelet aggregation induced by u-44069; the inhibition at 1 mg/kg was 100% at 1 hr and was 89% even at 24 hr after seratrodast administration [1].
References
[1] imura, y. ,terashita, z.,shibouta, y., et al. antagonistic action of aa-2414 on thromboxane a2/prostaglandin endoperoxide receptor in platelets and blood vessels. japanese journal of pharmacology 52(1), 35-53 (1990).
Properties of Seratrodast
Melting point: | 118-120°C |
Boiling point: | 522.3±49.0 °C(Predicted) |
Density | 1.140±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Yellow-orange solid. |
pka | 4.76±0.10(Predicted) |
color | Pale Orange to Yellow |
Merck | 14,8459 |
CAS DataBase Reference | 112665-43-7(CAS DataBase Reference) |
Safety information for Seratrodast
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Seratrodast
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