Scopoletin
Synonym(s):7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one;7-Hydroxy-6-methoxycoumarin;Chrysatropic acid;Gelseminic acid;6-Methylesculetin
- CAS NO.:92-61-5
- Empirical Formula: C10H8O4
- Molecular Weight: 192.17
- MDL number: MFCD00006872
- EINECS: 202-171-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 20:13:01
What is Scopoletin?
Chemical properties
Crystalline Solid
The Uses of Scopoletin
Scopoletin can be used for cosmetics, topical formulations, and foods.
The Uses of Scopoletin
Scopoletin is the aglucone of Scopolin. Used for cosmetics, topical formulations, and foods. Dyes and metabolites.
What are the applications of Application
Scopoletin is a dye used to detect release of reactive oxygen species such as peroxynitrite & inhibits acetylcholinesterase
Definition
ChEBI: A hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 3083, 1962 DOI: 10.1021/jo01056a023
General Description
Scopoletin is a coumarin compound and pharmacologically active chemical that is found in various plant species.
Biochem/physiol Actions
Scopoletin significantly increases activity of lipoprotein lipase in adipocytes by promoting transcription of the LPL gene. It also partially reverses inhibition of LPL by TNF-α.
Purification Methods
Crystallise it from water, acetic acid or *C6H6/MeOH. It is dimorphic with a second m at 193-195o. It sublimes at 120-130o/12mm. [Beilstein 18 H 99, 18 I 348, 18 II 68, 18 III/IV 1323, 18/3 V 203.]
Properties of Scopoletin
Melting point: | 203-205 °C (lit.) |
Boiling point: | 288.14°C (rough estimate) |
Density | 1.2932 (rough estimate) |
refractive index | 1.5430 (estimate) |
storage temp. | 2-8°C |
solubility | Chloroform (Sightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Sightl |
form | Crystalline Powder |
pka | 7.91±0.20(Predicted) |
color | Beige |
Water Solubility | Slightly soluble |
Merck | 14,8408 |
BRN | 156296 |
CAS DataBase Reference | 92-61-5(CAS DataBase Reference) |
NIST Chemistry Reference | 7-Hydroxy-6-methoxy-2h-1-benzopyran-2-one(92-61-5) |
EPA Substance Registry System | Scopoletin (92-61-5) |
Safety information for Scopoletin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Scopoletin
InChIKey | RODXRVNMMDRFIK-UHFFFAOYSA-N |
Abamectin manufacturer
CHROMOSYNTH PVT LTD
AVIGYABIOSCIENCES PRIVATE LIMITED
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