4-(Trifluoromethoxy)aniline
Synonym(s):α,α,α-Trifluoro-p-anisidine;4-(Trifluoromethoxy)aniline
- CAS NO.：461-82-5
- Empirical Formula: C7H6F3NO
- Molecular Weight: 177.12
- MDL number: MFCD00041314
- EINECS: 207-317-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 14:53:31
What is 4-(Trifluoromethoxy)aniline?
Chemical properties
CLEAR YELLOW LIQUID
The Uses of 4-(Trifluoromethoxy)aniline
4-(Trifluoromethoxy)aniline was used in the synthesis of:
- side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
- derivatives of 3-(quinolin-3-yl)acrylates
- series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves
The Uses of 4-(Trifluoromethoxy)aniline
4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.
Properties of 4-(Trifluoromethoxy)aniline
| Boiling point: | 73-75 °C10 mm Hg(lit.) |
| Density | 1.32 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 177 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 3.75±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.310 |
| BRN | 2090209 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2 |
| CAS DataBase Reference | 461-82-5(CAS DataBase Reference) |
Safety information for 4-(Trifluoromethoxy)aniline
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-(Trifluoromethoxy)aniline
| InChIKey | XUJFOSLZQITUOI-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OC(F)(F)F)C=C1 |
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product: 4-Trifluoromethoxy aniline 98%
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product: 4-Trifluoromethoxy aniline
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