SCOPARONE
Synonym(s):Scoparone;6,7-Dimethylesculetin;Aesculetin dimethyl ether;Escoparone;Esculetin 6,7-dimethyl ether
- CAS NO.:120-08-1
- Empirical Formula: C11H10O4
- Molecular Weight: 206.19
- MDL number: MFCD00006871
- EINECS: 204-369-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is SCOPARONE?
The Uses of SCOPARONE
Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.
What are the applications of Application
Scoparone is an agent that can up-regulate the expression and activate CAR
Definition
ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Synthesis Reference(s)
Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859
General Description
6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.
Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.
Properties of SCOPARONE
Melting point: | 143-145 °C (lit.) |
Boiling point: | 265.04°C (rough estimate) |
Density | 1.0858 (rough estimate) |
refractive index | 1.4389 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | >8.4mg/mL in DMSO |
form | Powder |
color | Light yellow to yellow |
Merck | 13,8479 |
CAS DataBase Reference | 120-08-1(CAS DataBase Reference) |
NIST Chemistry Reference | 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1) |
Safety information for SCOPARONE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SCOPARONE
Abamectin manufacturer
CHROMOSYNTH PVT LTD
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