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HomeProduct name listSCOPARONE

SCOPARONE

Synonym(s):Scoparone;6,7-Dimethylesculetin;Aesculetin dimethyl ether;Escoparone;Esculetin 6,7-dimethyl ether

  • CAS NO.:120-08-1
  • Empirical Formula: C11H10O4
  • Molecular Weight: 206.19
  • MDL number: MFCD00006871
  • EINECS: 204-369-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
SCOPARONE Structural

What is SCOPARONE?

The Uses of SCOPARONE

Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.

What are the applications of Application

Scoparone is an agent that can up-regulate the expression and activate CAR

Definition

ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.

Synthesis Reference(s)

Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859

General Description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.

Properties of SCOPARONE

Melting point: 143-145 °C (lit.)
Boiling point: 265.04°C (rough estimate)
Density  1.0858 (rough estimate)
refractive index  1.4389 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  >8.4mg/mL in DMSO
form  Powder
color  Light yellow to yellow
Merck  13,8479
CAS DataBase Reference 120-08-1(CAS DataBase Reference)
NIST Chemistry Reference 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1)

Safety information for SCOPARONE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for SCOPARONE

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