Schisandrin A

Synonym(s):Deoxyschisandrin;Deoxyschizandrin;Dimethylgomisin J;Schisandrin A;Schizandrin A

CAS NO.：61281-38-7
Empirical Formula: C24H32O6
Molecular Weight: 416.51
MDL number: MFCD00221760
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:13

What is Schisandrin A?

Description

Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC₅₀ = 3.2 μM). Schisandrin A (10, 20, and 50 μM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 μM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; ) in a mouse model of Alzheimer’s disease.

Chemical properties

White powder

The Uses of Schisandrin A

Schizandrin A is an extract from Schisandra chinesis. a dibenzocyclooctadiene lignan with antiinflammatory activity.

What are the applications of Application

Deoxyschizandrin is an agonist of the adiponectin receptor 2 (AdipoR2)

Properties of Schisandrin A

Melting point:	116-117 °C
Boiling point:	544.2±50.0 °C(Predicted)
Density	1.080±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder
color	White to Off-White

Safety information for Schisandrin A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.