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HomeProduct name listRS 504393

RS 504393

Synonym(s):6-Methyl-1′-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4′-piperidin]-2(1H)-one;RS-504393

RS 504393 Structural

What is RS 504393?

The Uses of RS 504393

RS 504393 is a small molecule antagonist at the CC chemokine receptor 2.

The Uses of RS 504393

RS504393 has been used in mass spectrometry.

What are the applications of Application

RS 504393 is an extremely selective CCR2 chemokine receptor antagonist and inhibitor of MCP-1 chemotaxis

Definition

ChEBI: 6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-2-spiro[1H-3,1-benzoxazine-4,4'-piperidine]one is a member of 1,3-oxazoles.

Biological Activity

Extremely selective CCR2 chemokine receptor antagonist (IC 50 values are 98 nM and > 100 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC 50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Biochem/physiol Actions

RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.

storage

Store at +4°C

Properties of RS 504393

Density  1.28
storage temp.  2-8°C
solubility  DMSO: soluble1mg/mL, clear (warmed)
form  powder
color  white to beige

Safety information for RS 504393

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for RS 504393

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