2-Methylpropanedioic acid

Chemical properties

white crystalline powder

The Uses of 2-Methylpropanedioic acid

2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

The Uses of 2-Methylpropanedioic acid

Methylmalonic acid can be used as a substrate in:

• Esterification reactions by various catalysts.
• Synthesis of pyrimidinium betaines with formamidine.
• Synthesis of malonic acid half thioester (MAHT).

Definition

ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Biological Functions

Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.

General Description

Methylmalonic acid is an indicator of vitamin B₁₂ deficiency and methylmalonic acidemia. This Certified Spiking Solution^? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

storage

Store at RT

Purification Methods

The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]