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HomeProduct name listRetinyl propionate

Retinyl propionate

Synonym(s):Retinyl propionate;Vitamin A propionate

  • CAS NO.:7069-42-3
  • Empirical Formula: C23H34O2
  • Molecular Weight: 342.51
  • MDL number: MFCD00129785
  • EINECS: 230-363-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-22 13:49:24
Retinyl propionate Structural

What is Retinyl propionate?

Description

Retinyl propionate (RP) is a less well-known, but pretty interesting member of the retinoids, aka the "royal family of skincare".Similar to retinyl palmitate, retinyl Propionate is also a retinol ester with retinol and propionic acid being attached together.

Chemical properties

Thick Yellow Oil

The Uses of Retinyl propionate

Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.

The Uses of Retinyl propionate

Retinyl Propionate is a Vitamin A ester derivative. Retinyl Propionate is a hypermitotic agent that is used in cosmetic formulations.This compound contains an unknown cis isomer.

What are the applications of Application

Retinyl propionate is Retinyl propionate is a retinoid which exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain

Biochem/physiol Actions

Retinyl propionate, a derivative of retinol, is a fatty acid that is used as a sample preparation for copper-complexed collagen[1]. In metabolic processes, retinyl propionate is metabolized primarily into retinol (ROL) in the viable epidermis and dermis whereas ROL is esterified into retinyl palmitate (RPalm) and metabolized into the inactive retinoid 14‐hydroxy‐4,14‐retro‐retinol (14‐HRR)[2]. Retinol and its derivatives effectively intervene in the skin aging process. The matrix effect of retinyl propionate can be seen in the skin cells, bone cells, and cartilage tissue. Retinyl propionate has been shown to increase calcium pantothenate transport rates in human serum and also has a film-forming polymer effect.

Side Effects

Side effects of using retinol may include: redness, irritation, burning, itching, dry skin, flaking and peeling of the skin, increased sensitivity to the sun, and skin cancer.

Structure and conformation

Retinyl propionate is closest in molecular size to pure retinoic acid with just three additional carbons. Vitamin A palmitate has an additional 16 carbons, making it too large to reach the dermis effectively.

References

[1] Wang Q, et al. The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging. Journal of Cosmetic Dermatology, 2023; 22: 2040-2049.
[2] Yang Y, et al. Hydrophobically modified inulin based nanoemulsions for enhanced stability and transdermal delivery of retinyl propionate. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022; 653: 129883.

Properties of Retinyl propionate

Boiling point: 453.7±14.0 °C(Predicted)
Density  0.963±0.06 g/cm3(Predicted)
vapor pressure  0-0Pa at 20-96.2℃
Flash point: 128 °C
storage temp.  2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form  Oil
color  Pale Yellow to Yellow Thick
BRN  2475675
Stability: Light Sensitive

Safety information for Retinyl propionate

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H360:Reproductive toxicity
H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P201:Obtain special instructions before use.
P273:Avoid release to the environment.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Retinyl propionate

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