Rafoxanide
Synonym(s):3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide
- CAS NO.:22662-39-1
- Empirical Formula: C19H11Cl2I2NO3
- Molecular Weight: 626.01
- MDL number: MFCD00682899
- EINECS: 245-148-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-28 18:20:31
What is Rafoxanide?
Chemical properties
Rafoxanide is a white to off-white solid,it is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).The solubility of rafoxanide in ethanol is approximately 2 mg/ml and approximately 30 mg/ml in DMSO and DMF.
The Uses of Rafoxanide
Rafoxanide is a thyroid hormone receptor.
Synthesis
The method includes preparing 2-chloro-4-nitrophenyl tert-chlorophenyl ether by adopting p-chlorophenol and 3,4-dichloronitrobenzene as raw materials and adopting DMF as a solvent under catalysis of a catalyst that is cuprous chloride, preparing 4-amino-2-chlorophenyl tert-chlorophenyl ether by hydrogenating under catalysis of a 10% Pd/C catalyst, reacting 3,5-diiodosalicylic acid that is adopted as a raw material with an acyl chlorination reagent that is BTC/C2H4Cl2 to prepare 3,5-diiodosalicyloyl chloride, and subjecting the 4-amino-2-chlorophenyl tert-chlorophenyl ether and the 3,5-diiodosalicyloyl chloride to condensation to prepare the rafoxanide.
Properties of Rafoxanide
Melting point: | 168-170° |
Boiling point: | 526.6±50.0 °C(Predicted) |
Density | 2.050±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
form | neat |
pka | 6.04±0.48(Predicted) |
form | Solid |
color | White to Off-White |
Merck | 14,8097 |
CAS DataBase Reference | 22662-39-1(CAS DataBase Reference) |
Safety information for Rafoxanide
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Rafoxanide
InChIKey | NEMNPWINWMHUMR-UHFFFAOYSA-N |
Rafoxanide manufacturer
Humble Healthcare Limited
Manasvi Life Sciences
Noven Lifesciences Pvt Limited
Nulli Secondus Impex Pvt Ltd
Heer Pharma Pvt Ltd
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