QUINOMYCIN A
Synonym(s):Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem;NSC-13502, Quinomycin A;Quinomycin A
- CAS NO.:512-64-1
- Empirical Formula: C51H64N12O12S2
- Molecular Weight: 1101.26
- MDL number: MFCD00156105
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-14 17:45:39
What is QUINOMYCIN A?
Description
Hypoxia-
The Uses of QUINOMYCIN A
Quiniomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumour agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumour progression and metastasis.
The Uses of QUINOMYCIN A
Quinomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis.
The Uses of QUINOMYCIN A
Echinomycin has been used for inhibition of hypoxia-inducible factor 1.
What are the applications of Application
Quinomycin A is an inhibitor of HIF
Biochem/physiol Actions
Echinomycin is an antitumor antibiotic and potent hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the binding of HIF-1α, a transcription factor important in tumor growth. Echinomycin selectively eliminated cancer stem cells in a study with mouse lymphoma and human AML xenogeneic models, eradicating the lymphomas. Recently, echinomycin was also found to act as an antibiotic adjuvant having synergistic effects with novobiocin in gram negative bacteria.
storage
Store at -20°C
References
1) Kong?et al.?(2005),?Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity; Cancer Res.,?65?9047 2) Wang?et al. (2014),?Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells; Blood,?124?1127 3) Wang?et al. (2011),?Targeting HIF1α eliminates cancer stem cells in hematological malignancies; Cell Stem Cell.,?8?399 4) Li?et al. (2015),?Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia; Cell Stress Chaperones,?20?507
Properties of QUINOMYCIN A
Melting point: | 217-218℃ |
alpha | D20 -310° (c = 0.86 in chloroform) |
Boiling point: | 1427.2±65.0 °C(Predicted) |
Density | 1.0964 (rough estimate) |
refractive index | 1.6700 (estimate) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 5 mg/ml) |
form | White solid |
pka | 9.38±0.70(Predicted) |
color | white to beige |
Merck | 13,3531 |
Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
Safety information for QUINOMYCIN A
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for QUINOMYCIN A
New Products
2,2-diethoxyethanethioamide Tubulysin D Tubulysin A Diethyl Aluminium Cyanide (1.0 M in Toluene) 3-Aminocyclobutanone hydrochloride 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1-(1,1-Difluoroethyl)-2-fluorobenzene 4,4-DIFLUOROPIPERIDINE Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one 2-Bromo-6- nitroanisole Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
Echinomycin CAS 512-64-1View Details
512-64-1 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
590-17-0 Bromoacetonitrile 98%View Details
590-17-0 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8