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HomeProduct name listCHAETOMIN

CHAETOMIN

Synonym(s):Chaetomin;CTM;NSC 289491

  • CAS NO.:1403-36-7
  • Empirical Formula: C31H30N6O6S4
  • Molecular Weight: 710.87
  • MDL number: MFCD28137713
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
CHAETOMIN Structural

What is CHAETOMIN?

The Uses of CHAETOMIN

Chetomin is an antibacterial agent and inhibitor of HIF.

What are the applications of Application

Chetomin is an antibacterial agent and inhibitor of HIF

Definition

ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.

Biochem/physiol Actions

Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.

storage

+4°C

Properties of CHAETOMIN

Melting point: 218-220℃ (chloroform )
Density  1.78±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: soluble
form  Off-white to fawn solid.
pka 12.69±0.10(Predicted)
color  Off-white to fawn

Safety information for CHAETOMIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for CHAETOMIN

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