CHAETOMIN
Synonym(s):Chaetomin;CTM;NSC 289491
- CAS NO.：1403-36-7
- Empirical Formula: C31H30N6O6S4
- Molecular Weight: 710.87
- MDL number: MFCD28137713
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CHAETOMIN?
The Uses of CHAETOMIN
Chetomin is an antibacterial agent and inhibitor of HIF.
What are the applications of Application
Chetomin is an antibacterial agent and inhibitor of HIF
Definition
ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
storage
+4°C
Properties of CHAETOMIN
| Melting point: | 218-220℃ (chloroform ) |
| Density | 1.78±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | Off-white to fawn solid. |
| pka | 12.69±0.10(Predicted) |
| color | Off-white to fawn |
Safety information for CHAETOMIN
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for CHAETOMIN
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 4-Hydrazinobenzoic acid 3,4-Dibenzyloxybenzaldehyde Electrolytic Iron Powder 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 3-(Hydroxymethyl)benzoate N-Boc-2-chloroethylamine 1-Bromo-2-methoxy-3-nitrobenzene N-Methyl-3-cyclopenten-1-amine 2-Bromo-3-hydroxybenzaldehyde 1H-indazole-5-carboxamideRelated products of tetrahydrofuran
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