4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
- CAS NO.:331830-20-7
- Empirical Formula: C13H8N2O3
- Molecular Weight: 240.21
- MDL number: MFCD07357380
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID?
Description
1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM).1 Inhibits collagen deposition via inhibition of collagen proline hydroxylation.2,3 Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury.4
The Uses of 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
1,4-DPCA nis a potent competitive inhibitor of avian prolyl 4-hydroxylase in embryonic chick tendon cells and human foreskin fibroblasts in vitro. It is a promotor of wound healing and tissue regeneration in mice.
What are the applications of Application
1,4-DPCA is a selective and potent inhibitor of P4HA (α-prolyl 4-hydroxylase)
References
1) Franklin?et al. (2001),?Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones; Biochem. J.,?353?333 2) Xiong?et al. (2014),?Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition; BMC Cancer,?14?1 3) Love and Jones?et al. (2013),?Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs; J. Biomed. Mater. Res.,?101?3599 4) Zhang?et al. (2015),?Drug induced regeneration in adult mice; Sci. Transl. Med.,?7?290ra92
Properties of 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
Boiling point: | 419.5±45.0 °C(Predicted) |
Density | 1.52±0.1 g/cm3(Predicted) |
storage temp. | RT |
solubility | Soluble in DMSO (up to 15 mg/ml with warming). |
form | Tan solid. |
pka | 2.55±0.20(Predicted) |
color | Off-white |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
Safety information for 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
Computed Descriptors for 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
New Products
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