Pyridoxine hydrochloride
Synonym(s):Pyridoxine hydrochloride;Pyridoxine HCl;5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride;Adermine hydrochloride;PN HCl
- CAS NO.:58-56-0
- Empirical Formula: C8H12ClNO3
- Molecular Weight: 205.64
- MDL number: MFCD08064207
- EINECS: 200-386-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Pyridoxine hydrochloride?
Chemical properties
White or almost white, crystalline powder.
The Uses of Pyridoxine hydrochloride
Pyridoxine is one of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). Pyridoxine has a role in transporting protein Bsu1, Pyridoxine contributes to thiamine uptak e; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.
The Uses of Pyridoxine hydrochloride
Pyridoxine Hydrochloride is an acid form of vitamin b6, a water- soluble vitamin. it is soluble in water, and slightly soluble in alco- hol. it is slowly affected by sunlight and is reasonably stable in air. it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride. see pyridoxine.
What are the applications of Application
Pyridoxine Hydrochloride is a vitamin of the B6 complex
What are the applications of Application
Pyridoxine is a form of vitamin B6
Definition
ChEBI: Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine. It is a hydrochloride and a vitamin B6. It contains a pyridoxine.
What are the applications of Application
Pyridoxine hydrochloride has been used:
As a vitamin component in a chemically defined diet with balanced metal content for metal depletion studies;
As a component of chemically defined medium (CDM) to culture Staphylococcus aureus WSPPA;
As analytical reference standards for the determination of analytes in pharmaceutical preparations by chromatography and spectrophotometric techniques;
As a vitamin to study the impact of protein expression and post-translational modifications specifically charge heterogeneity;
As a medicine, it is used to prevent or treat certain neurological disorders (peripheral neuropathy) caused by certain drugs (e.g. isoniazid). It is also used in the treatment of certain hereditary disorders (e.g. flavoururic aciduria, hyperoxaluria, homocystinuria).
brand name
Hexa-Betalin (Lilly).
General Description
Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine is a is a water-soluble vitamin and a pyrimidine derivative of vitamin B6. It is considered heat and acid stable.
Biochem/physiol Actions
Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy.
Clinical Use
Vitamin B6
Side Effects
Common side effects of Pyridoxine hydrochloride include: headache, nausea, drowsiness, mild numbness or tingling. Serious allergic reactions are rare and include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, decreased sensation of touch, temperature, and vibration; loss of balance or coordination. If serious side effects occur please seek medical attention.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Metabolism
Pyridoxine is metabolised to its active form pyridoxamine phosphate. It is stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.
Purification Methods
Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.]
Properties of Pyridoxine hydrochloride
Melting point: | 214-215 °C(lit.) |
Density | 1.2784 (rough estimate) |
vapor density | 7.1 (vs air) |
refractive index | 1.5800 (estimate) |
Flash point: | 9℃ |
storage temp. | room temp |
solubility | H2O: 0.1 g/mL at 20 °C, clear, colorless |
form | Crystalline Powder |
color | White to almost white |
PH Range | 3.2 |
Water Solubility | 0.1 g/mL (20 ºC) |
Sensitive | Light Sensitive |
Merck | 14,7982 |
BRN | 3632435 |
Stability: | Stable. Protect from air and light. |
CAS DataBase Reference | 58-56-0(CAS DataBase Reference) |
EPA Substance Registry System | 5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride (58-56-0) |
Safety information for Pyridoxine hydrochloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pyridoxine hydrochloride
Abamectin manufacturer
Meteoric Biopharmaceuticals Pvt. Ltd.
Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd)
Anand Agencies
Pharma Links
Bazayan & Co.
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