Pyridine sulfur trioxide

Synonym(s):NSC 75831;Pyridine sulfur trioxide complex;Sulfur trioxide pyridine complex

CAS NO.：26412-87-3
Empirical Formula: C5H5NO3S
Molecular Weight: 159.16
MDL number: MFCD00078270
EINECS: 247-683-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Pyridine sulfur trioxide?

Chemical properties

white solid

The Uses of Pyridine sulfur trioxide

Usually used for sulfations of alcohols, sulfonations, deoxygenations and other reductions, oxidations with DMSO.

The Uses of Pyridine sulfur trioxide

Pyridine-Sulfur Trioxide Complex is used in the sulfation of squid ink polysaccharides (SIPs) as a potential candidate compound for the prevention of tumor metastasis. Pyridine-Sulfur Trioxide Complex is also used in the preparation and anticoagulation test of sulfated silk fibroin.

The Uses of Pyridine sulfur trioxide

Sulfur trioxide-pyridine complex is used for sulfations of alcohols, sulfonations, deoxygenations and other reductions, oxidations with dimethyl sulfoxide. It is also used as a source of sulfur trioxide especially in the preparation of sulfate esters. Further, it is used as an activating electrophile in a Parikh-Doering oxidation. In addition to this, it is also used in the preparation and anticoagulation test of sulfated silk fibroin.

Purification Methods

Wash the solid with a little CCl4, then H2O to remove traces of pyridine sulfate, and dry it over P2O5. [Baumgarten Chem Ber 59 1166 1926, Olah et al. Synthesis 59 1979, Beilstein 20/5 V 184].

Properties of Pyridine sulfur trioxide

Melting point:	~160 °C
storage temp.	Store below +30°C.
solubility	Soluble in polar organic solvents.
form	Powder
color	White to beige
Water Solubility	reacts
Sensitive	Moisture Sensitive
BRN	3704116
CAS DataBase Reference	26412-87-3(CAS DataBase Reference)
EPA Substance Registry System	Pyridine sulfur trioxide (26412-87-3)

Safety information for Pyridine sulfur trioxide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.