N-(Trimethylsilyl)imidazole
Synonym(s):N-Trimethylsilylimidazole;N-(Trimethylsilyl)imidazole;TMSI;TSIM
- CAS NO.:18156-74-6
- Empirical Formula: C6H12N2Si
- Molecular Weight: 140.26
- MDL number: MFCD00005280
- EINECS: 242-040-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-19 17:50:00
What is N-(Trimethylsilyl)imidazole?
Chemical properties
Colorless transparent liquid
Physical properties
bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3.
The Uses of N-(Trimethylsilyl)imidazole
N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses.
The Uses of N-(Trimethylsilyl)imidazole
A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives.
The Uses of N-(Trimethylsilyl)imidazole
Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1
The Uses of N-(Trimethylsilyl)imidazole
N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency.
Definition
ChEBI: A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications.
General Description
1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers.
Properties of N-(Trimethylsilyl)imidazole
Melting point: | -42 °C |
Boiling point: | 93-94 °C14 mm Hg(lit.) |
Density | 0.957 g/mL at 20 °C |
refractive index | n |
Flash point: | 42 °F |
storage temp. | Store below +30°C. |
solubility | Chloroform |
form | Liquid |
pka | 7.96±0.10(Predicted) |
color | Clear colorless to yellow |
Specific Gravity | 0.956 |
Water Solubility | decomposes |
Sensitive | Moisture Sensitive |
Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
BRN | 606148 |
Stability: | Air and Moisture Sensitive |
CAS DataBase Reference | 18156-74-6(CAS DataBase Reference) |
NIST Chemistry Reference | 1h-Imidazole, 1-(trimethylsilyl)-(18156-74-6) |
EPA Substance Registry System | 1H-Imidazole, 1-(trimethylsilyl)- (18156-74-6) |
Safety information for N-(Trimethylsilyl)imidazole
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-(Trimethylsilyl)imidazole
InChIKey | YKFRUJSEPGHZFJ-UHFFFAOYSA-N |
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