Pyridine-N-oxide

CAS NO.：694-59-7
Empirical Formula: C5H5NO
Molecular Weight: 95.1
MDL number: MFCD00006194
EINECS: 211-774-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-11 14:08:43

What is Pyridine-N-oxide?

Chemical properties

White to light yellow solid

The Uses of Pyridine-N-oxide

Intermediate.

The Uses of Pyridine-N-oxide

Pyridine N-Oxide is a useful reagent for the chemical industry, a mild reoxidant that transforms osmium-catalyzed oxidative cyclization. A catalytic agent.

Definition

ChEBI: The pyridine N-oxide derived from the parent pyridine. It is a drug metabolite of the antihypertensive agent pinacidil.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 828, 1963
Tetrahedron Letters, 12, p. 2807, 1971 DOI: 10.1016/S0040-4039(01)97047-9

General Description

Pyridine N-oxide axle with [2]rotaxanes was synthesized via an anion templated threading-followed-by-stoppering strategy.

Hazard

Probably flammable and toxic.

Purification Methods

Purify the N-oxide by crystallisation from Et2O and by vacuum sublimation. The picrolonate has m 182-184o. [Katritzky J Chem Soc 2407 1956, Beilstein 20 III/IV 2305, 20/5 V 217.]

Properties of Pyridine-N-oxide

Melting point:	62-67 °C(lit.)
Boiling point:	270 °C(lit.)
Density	1.1418 (rough estimate)
refractive index	1.5939 (estimate)
Flash point:	143 °C
storage temp.	2-8°C
form	Crystalline Solid, Crystals, and/or Chunks
pka	0.79(at 24℃)
color	White to brownish
Water Solubility	soluble
Sensitive	Hygroscopic
Merck	14,7972
BRN	105257
CAS DataBase Reference	694-59-7(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 1-oxide(694-59-7)
EPA Substance Registry System	Pyridine, 1-oxide (694-59-7)

Safety information for Pyridine-N-oxide

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.