PROSTAGLANDIN B1
Synonym(s):(13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid;PGB1
- CAS NO.:13345-51-2
- Empirical Formula: C20H32O4
- Molecular Weight: 336.47
- MDL number: MFCD00036679
- EINECS: 234-237-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:33
What is PROSTAGLANDIN B1?
The Uses of PROSTAGLANDIN B1
Prostaglandin B1 is a novel microbial biopolymer which has been shown to improve the longevity of type 2 diabetic rodents. Oligomers of prostaglandin B1 inhibit arachidonic acid mobilization in human neutrophils and endothelial cells.
What are the applications of Application
PGB1 (Prostaglandin B1) is a metabolite of PGA1 shown to modify the pressor responses to sympathetic nerve stimulation
Definition
ChEBI: Prostaglandin B1 is a member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer). It has a role as a human metabolite. It is a conjugate acid of a prostaglandin B1(1-).
Enzyme inhibitor
This eicosanoid (FWB1 (free-acid) = 336.47 g/mol; CAS 13345-51-2, for PGB1, and 39306-29-1, for Bx) is a metabolite of prostaglandin E1: prostaglandin Bx is an oligomer of prostaglandin B1. The X-ray crystal structure of prostaglandin B1 suggests this prostaglandin has an unusual L-shaped configuration, with the a and w side chains roughly perpendicular to one another. The 15-hydroxyl group, which is normally directed away from the centroid of the prostaglandin in the standard hairpin mod+el, is turned inward in prostaglandin B1. Target (s) : FoF1 ATPase, or H-transporting two-sector ATPase, inhibited by prostaglandin Bx; 15- hydroxyprostaglandin dehydrogenase; phospholipase A2, inhibited by prostaglandin Bx.
Properties of PROSTAGLANDIN B1
Melting point: | 69-71°C |
Boiling point: | 531.4±43.0 °C(Predicted) |
Density | 1.101±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | acetone: 20 mg/mL, clear, colorless to very faintly yellow |
form | powder |
pka | 4.77±0.10(Predicted) |
color | white to light yellow |
BRN | 2004447 |
Stability: | Light Sensitive |
Safety information for PROSTAGLANDIN B1
Computed Descriptors for PROSTAGLANDIN B1
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