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HomeProduct name listPROSTAGLANDIN B1

PROSTAGLANDIN B1

Synonym(s):(13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-oic acid;PGB1

  • CAS NO.:13345-51-2
  • Empirical Formula: C20H32O4
  • Molecular Weight: 336.47
  • MDL number: MFCD00036679
  • EINECS: 234-237-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:33
PROSTAGLANDIN B1 Structural

What is PROSTAGLANDIN B1?

The Uses of PROSTAGLANDIN B1

Prostaglandin B1 is a novel microbial biopolymer which has been shown to improve the longevity of type 2 diabetic rodents. Oligomers of prostaglandin B1 inhibit arachidonic acid mobilization in human neutrophils and endothelial cells.

What are the applications of Application

PGB1 (Prostaglandin B1) is a metabolite of PGA1 shown to modify the pressor responses to sympathetic nerve stimulation

Definition

ChEBI: Prostaglandin B1 is a member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer). It has a role as a human metabolite. It is a conjugate acid of a prostaglandin B1(1-).

Enzyme inhibitor

This eicosanoid (FWB1 (free-acid) = 336.47 g/mol; CAS 13345-51-2, for PGB1, and 39306-29-1, for Bx) is a metabolite of prostaglandin E1: prostaglandin Bx is an oligomer of prostaglandin B1. The X-ray crystal structure of prostaglandin B1 suggests this prostaglandin has an unusual L-shaped configuration, with the a and w side chains roughly perpendicular to one another. The 15-hydroxyl group, which is normally directed away from the centroid of the prostaglandin in the standard hairpin mod+el, is turned inward in prostaglandin B1. Target (s) : FoF1 ATPase, or H-transporting two-sector ATPase, inhibited by prostaglandin Bx; 15- hydroxyprostaglandin dehydrogenase; phospholipase A2, inhibited by prostaglandin Bx.

Properties of PROSTAGLANDIN B1

Melting point: 69-71°C
Boiling point: 531.4±43.0 °C(Predicted)
Density  1.101±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  acetone: 20 mg/mL, clear, colorless to very faintly yellow
form  powder
pka 4.77±0.10(Predicted)
color  white to light yellow
BRN  2004447
Stability: Light Sensitive

Safety information for PROSTAGLANDIN B1

Computed Descriptors for PROSTAGLANDIN B1

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