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HomeProduct name list5,6BETA-DIHYDRO PGI2

5,6BETA-DIHYDRO PGI2

5,6BETA-DIHYDRO PGI2 Structural

What is 5,6BETA-DIHYDRO PGI2?

Description

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

What are the applications of Application

6β-Prostaglandin I1 is a hydrolytically stable PGI2 analog

Definition

ChEBI: 6-Prostaglandin I1 is a prostanoid.

References

1. Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin — a potent stable prostacyclin analogue for the inhibition of platelet aggregation Prostaglandins 19(4),605-627(1980).
2. Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships Br. J. Pharmac. 69(3),519-525(1980).

Properties of 5,6BETA-DIHYDRO PGI2

storage temp.  Store at -20°C
solubility  DMF: >10 mg/ml; DMSO: >5 mg/ml; Ethanol: >20 mg/ml; PBS pH 7.2: >80 μg/ml
form  A crystalline solid

Safety information for 5,6BETA-DIHYDRO PGI2

Computed Descriptors for 5,6BETA-DIHYDRO PGI2

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