PROSTACYCLIN SODIUM SALT

Description

Epoprostenol is a naturally occurring prostaglandin indicated for the preservation of platelet function during cardiopulmonary bypass, prevention of platelet aggregation during charcoal hemoperfusion of patients in hepatic failure, and as an alternative to heparin during renal dialysis.

Chemical properties

Epoprostenol is white crystalline powder

Originator

Burroughs Wellcome (United Kingdom)

The Uses of PROSTACYCLIN SODIUM SALT

Epoprostenol is an Eicosanoid which prevents the formation of platelet plugs and is an effective vasodilator.

The Uses of PROSTACYCLIN SODIUM SALT

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure
• as supplement in platelet-rich-plasma, for platelet preparation
• to prevent platelet activation

What are the applications of Application

Prostaglandin I2 sodium is an eiconasoid shown to induce vasodilation and inhibit platelet aggregation.

Manufacturing Process

Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE, SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min and the resulting supernatant centrifuged again for 5 min. The pellet was discarded, while the pellet obtained after centrifugation of the supernatant was resuspended in deionized water and lyophilized. An average yield of 150 mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was obtained.

brand name

Flolan (GlaxoSmithKline);CYCLO-PROSTIN.

Therapeutic Function

Platelet aggregation inhibitor, Antimetastatic

Biological Activity

Epoprostenol is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Biochem/physiol Actions

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

storage

Desiccate at -80°C