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HomeProduct name listLEUKOTRIENE D4

LEUKOTRIENE D4

Synonym(s):LTD4

LEUKOTRIENE D4 Structural

What is LEUKOTRIENE D4?

Description

Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.

The Uses of LEUKOTRIENE D4

LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle.

What are the applications of Application

LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle

Definition

ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).

Biochem/physiol Actions

Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.

Properties of LEUKOTRIENE D4

Boiling point: 785.8±60.0 °C(Predicted)
Density  1.162±0.06 g/cm3(Predicted)
Flash point: 9℃
storage temp.  -70°C
solubility  A solution in ethanol
form  Liquid.
pka 3.03±0.10(Predicted)
color  Colorless to light yellow

Safety information for LEUKOTRIENE D4

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for LEUKOTRIENE D4

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