LEUKOTRIENE D4
Synonym(s):LTD4
- CAS NO.:73836-78-9
- Empirical Formula: C25H40N2O6S
- Molecular Weight: 496.66
- MDL number: MFCD00036839
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is LEUKOTRIENE D4?
Description
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
The Uses of LEUKOTRIENE D4
LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle.
What are the applications of Application
LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle
Definition
ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).
Biochem/physiol Actions
Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.
Properties of LEUKOTRIENE D4
Boiling point: | 785.8±60.0 °C(Predicted) |
Density | 1.162±0.06 g/cm3(Predicted) |
Flash point: | 9℃ |
storage temp. | -70°C |
solubility | A solution in ethanol |
form | Liquid. |
pka | 3.03±0.10(Predicted) |
color | Colorless to light yellow |
Safety information for LEUKOTRIENE D4
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for LEUKOTRIENE D4
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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