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HomeProduct name listProcaine penicilline G hydrate

Procaine penicilline G hydrate

  • CAS NO.:6130-64-9
  • Empirical Formula: C29H38N4O6S
  • Molecular Weight: 570.71
  • MDL number: MFCD00150771
  • EINECS: 612-112-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
Procaine penicilline G hydrate Structural

What is Procaine penicilline G hydrate?

Description

Benzylpenicillin procaine was developed as a dilatorily acting benzylpenicillin, only slightly soluble in water. It has been used with peanut oil or carboxymethylcellulose as an oil suspension or an aqueous suspension, respectively .

Chemical properties

White Solid

The Uses of Procaine penicilline G hydrate

Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.

The Uses of Procaine penicilline G hydrate

Procaine Penicillin G is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.

What are the applications of Application

Penicillin G procaine is a combination of Penicillin G and Procaine

brand name

Duracillin(Lilly); Pfizerpen (Pfizer).

Antimicrobial activity

The procaine salt of benzylpenicillin. Poorly soluble (1:200 in water). Administered intramuscularly as a suspension of crystals which slowly dissolve at the site of the injection.
It must not be given intravenously. Intramuscular administration produces a flat sustained plasma concentration of penicillin, which is much lower than that achieved by an equivalent dose of benzylpenicillin, with plasma levels still detectable 24 h later. An injection of 0.6 g yields a peak plasma concentration of 1–2 mg benzylpenicillin/L after 2–4 h. Free procaine is detectable in the plasma within 30 min.
Very severe and potentially fatal reactions resembling those of anaphylactic shock, but non-allergic in character, may occur, probably due to accidental entry into the vascular system at the site of injection and blockage of pulmonary and cerebral capillaries by crystals of the suspension. Reactions due to liberated procaine may include acute anxiety, hypertension, tachycardia, vomiting, audiovisual hallucinations and acute psychotic disturbance. The most severe reactions lead to convulsions and cardiac arrest. Other reactions are those to liberated benzylpenicillin.

Properties of Procaine penicilline G hydrate

Melting point: 106-110° (with decompn)
Density  1.255-1.256
storage temp.  Refrigerator
solubility  Slightly soluble in water, sparingly soluble in ethanol (96 per cent).
form  neat
form  Solid
color  White to Off-White
CAS DataBase Reference 6130-64-9(CAS DataBase Reference)

Safety information for Procaine penicilline G hydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Procaine penicilline G hydrate

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