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HomeProduct name listPristinamycin IA

Pristinamycin IA

Pristinamycin IA Structural

What is Pristinamycin IA?

The Uses of Pristinamycin IA

One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).

The Uses of Pristinamycin IA

Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Definition

ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.

What are the applications of Application

Virginiamycin B is a depsipeptide antibiotic

Contact allergens

Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.

Properties of Pristinamycin IA

Melting point: 198°
Boiling point: 780.3°C (rough estimate)
alpha  D22 -57.5° (c = 0.25 in ethanol)
Density  1.1881 (rough estimate)
refractive index  1.6910 (estimate)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
pka pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain)
form  Solid
color  Pale Yellow

Safety information for Pristinamycin IA

Computed Descriptors for Pristinamycin IA

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