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HomeProduct name listLisinopril Dihydrate

Lisinopril Dihydrate

Synonym(s):(S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate;Lisinopril;MK-521

  • CAS NO.:83915-83-7
  • Empirical Formula: C21H33N3O6
  • Molecular Weight: 423.51
  • MDL number: MFCD08064198
  • EINECS: 627-033-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
Lisinopril Dihydrate Structural

What is Lisinopril Dihydrate?

Description

Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.

Description

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used primarily to treat hypertension, congestive heart failure, and heart attacks and to prevent renal and retinal complications of diabetes. It was developed by Merck and is marketed worldwide by Merck, AstraZeneca, Micro Labs, and generic drug suppliers. [Taken from Wikipedia—Ed.]

Chemical properties

White to Off-White Crystalline Powder

Originator

Merck (USA)

The Uses of Lisinopril Dihydrate

An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril

The Uses of Lisinopril Dihydrate

An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.

The Uses of Lisinopril Dihydrate

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.

brand name

Prinivil (Merck); Zestril (AstraZeneca).

General Description

Lisinopril, 1-[N2-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Clinical Use

Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.

Veterinary Drugs and Treatments

The principle uses of lisinopril in veterinary medicine at present are as a vasodilator in the treatment of heart failure or hypertension. Recent studies have demonstrated that ACE inhibitors, particularly when used in conjunction with furosemide, do improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. Lisinopril may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and in protein losing nephropathies.
Lisinopril may have advantages over other ACE inhibitors in that it may be dosed once daily and less expensive. Disadvantages are that it is only available in human labeled dosage forms and there is much less published information on its use (efficacy, safety, dosing) in veterinary species.

Properties of Lisinopril Dihydrate

Melting point: 148 °C
alpha  25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
refractive index  -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
storage temp.  2-8°C
solubility  H2O: ≥10 mg/mL
form  solid
pka 2.5, 4.0, 6.7, 10.1(at 25℃)
color  white
Merck  14,5516
Stability: Hygroscopic
CAS DataBase Reference 83915-83-7(CAS DataBase Reference)
EPA Substance Registry System L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7)

Safety information for Lisinopril Dihydrate

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Lisinopril Dihydrate

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