Pranoprofen
Synonym(s):2-(5H-[1]-Benzopyrano[2,3-b]pyridin-7-yl)propionic acid;2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
- CAS NO.：52549-17-4
- Empirical Formula: C15H13NO3
- Molecular Weight: 255.27
- MDL number: MFCD00866111
- EINECS: 682-035-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 15:18:15
What is Pranoprofen?
Chemical properties
Off-White Solid
Originator
Niflan, Yoshitomi ,Japan ,1981
The Uses of Pranoprofen
Pranoprofen is an anti-inflammatory used in ophthalmology.
What are the applications of Application
Pranoprofen is a non-steroidal antiinflammatory
Definition
ChEBI: Pranoprofen is a pyridochromene.
Manufacturing Process
A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.
Therapeutic Function
Analgesic, Antiinflammatory
General Description
Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.
Biochem/physiol Actions
Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.
Properties of Pranoprofen
| Melting point: | 182-183° |
| Boiling point: | 398.5°C (rough estimate) |
| Density | 1.1654 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.27±0.10(Predicted) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 52549-17-4(CAS DataBase Reference) |
Safety information for Pranoprofen
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for Pranoprofen
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