COMPUTED DESCRIPTORS
Molecular Weight | 491.3 g/mol |
---|---|
XLogP3 | 5.4 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 7 |
Rotatable Bond Count | 6 |
Exact Mass | 490.0974741 g/mol |
Monoisotopic Mass | 490.0974741 g/mol |
Topological Polar Surface Area | 76.6 Ų |
Heavy Atom Count | 33 |
Formal Charge | 0 |
Complexity | 684 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Poziotinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations. It has a role as an antineoplastic agent, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is a member of quinazolines, a N-acylpiperidine, an aromatic ether, a diether, a secondary amino compound, a dichlorobenzene, a member of monofluorobenzenes, a substituted aniline and a member of acrylamides.