PD168393
Synonym(s):4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline;4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide;PD 168393;PD 168393 - CAS 194423-15-9 - Calbiochem
- CAS NO.：194423-15-9
- Empirical Formula: C17H13BrN4O
- Molecular Weight: 369.22
- MDL number: MFCD02179207
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is PD168393?
The Uses of PD168393
PD168393 has been used in the acute inhibition of ErbB4.
The Uses of PD168393
PD 168393, is an irreversible epidermal growth factor receptor (EGFR) inhibitor.
What are the applications of Application
PD 168393 is a potent, cell-permeable, irreversible inhibitor of EGFR
Definition
ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.
Biochem/physiol Actions
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
Properties of PD168393
| Melting point: | 279℃ |
| Boiling point: | 571.1±50.0 °C(Predicted) |
| Density | 1.558±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | insoluble in H2O; ≥1 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.45 mg/mL in DMSO |
| form | powder |
| pka | 12.19±0.43(Predicted) |
| color | white to beige |
Safety information for PD168393
Computed Descriptors for PD168393
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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