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HomeProduct name listPotassium canrenoate

Potassium canrenoate

  • CAS NO.:2181-04-6
  • Empirical Formula: C11H15KO2
  • Molecular Weight: 218.33
  • MDL number: MFCD00058500
  • EINECS: 218-554-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-17 16:00:36
Potassium canrenoate Structural

What is Potassium canrenoate?

Originator

Spiroctan,Boehringer Mannheim,Switz.,1968

The Uses of Potassium canrenoate

anticholithogenic, antilipemic agent

The Uses of Potassium canrenoate

Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.

What are the applications of Application

Potassium canrenoate is a competitive aldosterone antagonist

Manufacturing Process

The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.

brand name

Aldactone-diurapid;Aldadiene potassium;Kadiur;Lasiren;Luvion;Osirenol;Osyrol-lasix;Phanurane;Sincomen pro injectione;Speroctan-m;Spiroctan.

Therapeutic Function

Aldosterone antagonist, Diuretic

World Health Organization (WHO)

Potassium canrenoate, which has no intrinsic aldosterone antagonist activity, owes its therapeutic effect to the enzymatic interconversion in the body to canrenone. Evidence that long-term administration of high doses are tumorigenic in the rat has recently led to restriction of its use by some national regulatory authorities. See also WHO comments for canrenone and spironolactone.

Properties of Potassium canrenoate

Melting point: 242-244°C (dec.)
Density  1.345 g/cm3
storage temp.  Refrigerator
solubility  Methanol (Slightly)
form  powder
color  light yellow to tan
CAS DataBase Reference 2181-04-6(CAS DataBase Reference)

Safety information for Potassium canrenoate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.

Computed Descriptors for Potassium canrenoate

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