Polyinosinic acid-polycytidylic acid

CAS NO.：24939-03-5
Empirical Formula: C19H27N7O16P2
Molecular Weight: 671.41
MDL number: MFCD00131957
EINECS: 1308068-626-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 19:05:58

What is Polyinosinic acid-polycytidylic acid?

The Uses of Polyinosinic acid-polycytidylic acid

Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.

Definition

ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.

Biological Activity

poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.

Properties of Polyinosinic acid-polycytidylic acid

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Water (Slightly)
form	Solid
color	White to Off-White
Water Solubility	Soluble to 3 mg/ml in water
Stability:	Hygroscopic

Safety information for Polyinosinic acid-polycytidylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H402:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Polyinosinic acid-polycytidylic acid

InChIKey	ACEVNMQDUCOKHT-WOQDZEJINA-N
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O \|&1:1,2,3,11,22,23,24,32,r\|