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HomeProduct name listL-DIHYDROOROTIC ACID

L-DIHYDROOROTIC ACID

Synonym(s):L-Hydroorotic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;Dihydro-L-orotic acid

  • CAS NO.:5988-19-2
  • Empirical Formula: C5H6N2O4
  • Molecular Weight: 158.11
  • MDL number: MFCD00085339
  • EINECS: 624-952-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
L-DIHYDROOROTIC ACID Structural

What is L-DIHYDROOROTIC ACID?

Chemical properties

White to off-white crystalline powder

The Uses of L-DIHYDROOROTIC ACID

L-Dihydroorotic acid a metabolite.

What are the applications of Application

L-Dihydroorotic acid is a metabolite

Definition

ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

Properties of L-DIHYDROOROTIC ACID

Melting point: 254-255 °C (dec.)(lit.)
Boiling point: 283.16°C (rough estimate)
Density  1.523
refractive index  1.5090 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Water (Slightly, Heated, Sonicated)
form  Powder
pka 2.82±0.20(Predicted)
color  White to off-white
Water Solubility  Soluble in water (partly), and dimethyl formamide.
CAS DataBase Reference 5988-19-2(CAS DataBase Reference)
NIST Chemistry Reference Orotic acid, dihydro-, l-(5988-19-2)

Safety information for L-DIHYDROOROTIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L-DIHYDROOROTIC ACID

InChIKey UFIVEPVSAGBUSI-REOHCLBHSA-N

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