L-DIHYDROOROTIC ACID
Synonym(s):L -Hydroorotic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;Dihydro-L -orotic acid
- CAS NO.：5988-19-2
- Empirical Formula: C5H6N2O4
- Molecular Weight: 158.11
- MDL number: MFCD00085339
- EINECS: 624-952-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 17:43:10
What is L-DIHYDROOROTIC ACID?
Chemical properties
White to off-white crystalline powder
The Uses of L-DIHYDROOROTIC ACID
L-Dihydroorotic acid a metabolite.
What are the applications of Application
L-Dihydroorotic acid is a metabolite
Definition
ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
Biochem/physiol Actions
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
Properties of L-DIHYDROOROTIC ACID
| Melting point: | 254-255 °C (dec.)(lit.) |
| Boiling point: | 283.16°C (rough estimate) |
| Density | 1.523 |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) |
| form | Powder |
| pka | 2.82±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble in water (partly), and dimethyl formamide. |
| CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
Safety information for L-DIHYDROOROTIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-DIHYDROOROTIC ACID
| InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N |
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