L-DIHYDROOROTIC ACID

Synonym(s):L-Hydroorotic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;Dihydro-L-orotic acid

CAS NO.：5988-19-2
Empirical Formula: C5H6N2O4
Molecular Weight: 158.11
MDL number: MFCD00085339
EINECS: 624-952-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 18:52:02

What is L-DIHYDROOROTIC ACID?

Chemical properties

White to off-white crystalline powder

The Uses of L-DIHYDROOROTIC ACID

L-Dihydroorotic acid a metabolite.

What are the applications of Application

L-Dihydroorotic acid is a metabolite

Definition

ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

Properties of L-DIHYDROOROTIC ACID

Melting point:	254-255 °C (dec.)(lit.)
Boiling point:	283.16°C (rough estimate)
Density	1.523
refractive index	1.5090 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Water (Slightly, Heated, Sonicated)
form	Powder
pka	2.82±0.20(Predicted)
color	White to off-white
Water Solubility	Soluble in water (partly), and dimethyl formamide.
CAS DataBase Reference	5988-19-2(CAS DataBase Reference)
NIST Chemistry Reference	Orotic acid, dihydro-, l-(5988-19-2)

Safety information for L-DIHYDROOROTIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.