L-DIHYDROOROTIC ACID
Synonym(s):L -Hydroorotic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;Dihydro-L -orotic acid
- CAS NO.:5988-19-2
- Empirical Formula: C5H6N2O4
- Molecular Weight: 158.11
- MDL number: MFCD00085339
- EINECS: 624-952-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is L-DIHYDROOROTIC ACID?
Chemical properties
White to off-white crystalline powder
The Uses of L-DIHYDROOROTIC ACID
L-Dihydroorotic acid a metabolite.
What are the applications of Application
L-Dihydroorotic acid is a metabolite
Definition
ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
Biochem/physiol Actions
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
Properties of L-DIHYDROOROTIC ACID
Melting point: | 254-255 °C (dec.)(lit.) |
Boiling point: | 283.16°C (rough estimate) |
Density | 1.523 |
refractive index | 1.5090 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) |
form | Powder |
pka | 2.82±0.20(Predicted) |
color | White to off-white |
Water Solubility | Soluble in water (partly), and dimethyl formamide. |
CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) |
NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
Safety information for L-DIHYDROOROTIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-DIHYDROOROTIC ACID
InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N |
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
You may like
-
L-Dihydroorotic acid 98% (HPLC) CAS 5988-19-2View Details
5988-19-2 -
L-Dihydroorotic acid CAS 5988-19-2View Details
5988-19-2 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
2, 4-Pyrimidinediamine 3-Oxide 99%View Details
74638-76-9 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
(−)-Dip-Chloride 85116-37-6 99%View Details
85116-37-6