PNU 37883 hydrochloride

What are the applications of Application

U-37883A is a potent inhibitor of vascular smooth muscle KIR6 channels

Biological Activity

Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects.

storage

room temperature (desiccate)