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HomeProduct name listGabapentin-lactam

Gabapentin-lactam

Synonym(s):3-Azaspiro[4.5]decan-2-one;4,4-Pentamethylene-2-pyrrolidinone;4,4-PENTAMETHYLENE-2-PYRROLIDONE;Gabapentin Impurity A

  • CAS NO.:64744-50-9
  • Empirical Formula: C9H15NO
  • Molecular Weight: 153.22
  • MDL number: MFCD00177938
  • EINECS: 451-630-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:41
Gabapentin-lactam Structural

What is Gabapentin-lactam?

Description

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

Chemical properties

Gabapentin-lactam is White Solid

The Uses of Gabapentin-lactam

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

The Uses of Gabapentin-lactam

Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels

The Uses of Gabapentin-lactam

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

What are the applications of Application

Gabapentin-lactam is a potassium channel modulator and potential neuroprotector

Definition

ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

References

1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845

Properties of Gabapentin-lactam

Melting point: 84-89 °C(lit.)
Boiling point: 181 °C / 13mmHg
Density  1.05±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 40 mg/ml)
pka 16.39±0.20(Predicted)
form  neat
color  White
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference 64744-50-9(CAS DataBase Reference)

Safety information for Gabapentin-lactam

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Gabapentin-lactam

InChIKey JAWPQJDOQPSNIQ-UHFFFAOYSA-N

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