Gabapentin-lactam
Synonym(s):3-Azaspiro[4.5]decan-2-one;4,4-Pentamethylene-2-pyrrolidinone;4,4-PENTAMETHYLENE-2-PYRROLIDONE;Gabapentin Impurity A
- CAS NO.:64744-50-9
- Empirical Formula: C9H15NO
- Molecular Weight: 153.22
- MDL number: MFCD00177938
- EINECS: 451-630-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is Gabapentin-lactam?
Description
Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4
Chemical properties
Gabapentin-lactam is White Solid
The Uses of Gabapentin-lactam
Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
The Uses of Gabapentin-lactam
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
The Uses of Gabapentin-lactam
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
What are the applications of Application
Gabapentin-lactam is a potassium channel modulator and potential neuroprotector
Definition
ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
References
1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845
Properties of Gabapentin-lactam
Melting point: | 84-89 °C(lit.) |
Boiling point: | 181 °C / 13mmHg |
Density | 1.05±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 40 mg/ml) |
pka | 16.39±0.20(Predicted) |
form | neat |
color | White |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 64744-50-9(CAS DataBase Reference) |
Safety information for Gabapentin-lactam
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Gabapentin-lactam
InChIKey | JAWPQJDOQPSNIQ-UHFFFAOYSA-N |
Gabapentin-lactam manufacturer
GRK RESEARCH LABORATORIES PVT LTD
IOL Chemicals And Pharmaceuticals Limited
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