Pleuromulin
Synonym(s):Drosophilin B;Mutilin 14-glycolate;NSC 121145
- CAS NO.:125-65-5
- Empirical Formula: C22H34O5
- Molecular Weight: 378.5
- MDL number: MFCD28154633
- EINECS: 204-747-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-28 13:16:12
What is Pleuromulin?
Description
Pleuromutilin is an antibiotic derived from the fungus Clitopilus that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.
Chemical properties
Pleuromulin is Crystalline Solid
The Uses of Pleuromulin
Antibiotic substance produced by the basidiomycetes Pleurotus mutilus
The Uses of Pleuromulin
Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.
The Uses of Pleuromulin
Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.
What are the applications of Application
Pleuromutilin is a potent diterpene antibiotic with activity against Gram positive bacteria
References
[1]. kilaru s, collins cm, hartley aj, et al. establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus clitopilus passeckerianus. appl environ microbiol. 2009 nov;75(22):7196-204.
[2]. long ks, hansen lh, jakobsen l, et al. interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. antimicrob agents chemother. 2006 apr;50(4):1458-62.
Properties of Pleuromulin
Melting point: | 170-1710C |
Boiling point: | 482.8±45.0 °C(Predicted) |
alpha | D24 +20° (c = 3 in abs ethanol) |
Density | 1.15±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO: >10mg/mL (warmed) |
form | powder |
pka | 12.91±0.10(Predicted) |
color | white to beige |
optical activity | [α]/D +30 to +40° (c=1; CH2Cl2) |
Safety information for Pleuromulin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Pleuromulin
InChIKey | YSBXUHAJXRCCET-BKUNHTPHSA-N |
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