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HomeProduct name listPinostrobin

Pinostrobin

  • CAS NO.:480-37-5
  • Empirical Formula: C16H14O4
  • Molecular Weight: 270.28
  • MDL number: MFCD06858342
  • EINECS: 207-548-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-11 15:28:25
Pinostrobin Structural

What is Pinostrobin?

Description

Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).

The Uses of Pinostrobin

Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy.

Definition

ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.

Properties of Pinostrobin

Melting point: 100°C
Boiling point: 494.9±45.0 °C(Predicted)
Density  1.284±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml
form  A crystalline solid
pka 7.40±0.40(Predicted)
color  White to yellow

Safety information for Pinostrobin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pinostrobin

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