Pinostrobin
- CAS NO.:480-37-5
- Empirical Formula: C16H14O4
- Molecular Weight: 270.28
- MDL number: MFCD06858342
- EINECS: 207-548-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-11 15:28:25
What is Pinostrobin?
Description
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).
The Uses of Pinostrobin
Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy.
Definition
ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.
Properties of Pinostrobin
Melting point: | 100°C |
Boiling point: | 494.9±45.0 °C(Predicted) |
Density | 1.284±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml |
form | A crystalline solid |
pka | 7.40±0.40(Predicted) |
color | White to yellow |
Safety information for Pinostrobin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pinostrobin
Abamectin manufacturer
CHROMOSYNTH PVT LTD
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