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HomeProduct name listPhthalazine

Phthalazine

Synonym(s):β-Phenodiazine;2,3-Benzodiazine;Phthalazine

  • CAS NO.:253-52-1
  • Empirical Formula: C8H6N2
  • Molecular Weight: 130.15
  • MDL number: MFCD00006908
  • EINECS: 205-963-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-27 11:36:15
Phthalazine Structural

What is Phthalazine?

Chemical properties

SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER

The Uses of Phthalazine

Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors.

The Uses of Phthalazine

Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia.

Definition

ChEBI: Phthalazine is an azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. It is a mancude organic heterobicyclic parent, a member of phthalazines, an azaarene and an ortho-fused heteroarene.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219

Purification Methods

Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.]

Properties of Phthalazine

Melting point: 89-92 °C(lit.)
Boiling point: 189 °C29 mm Hg(lit.)
Density  1.1509 (rough estimate)
refractive index  1.6231 (estimate)
Flash point: 178-180°C/15mm
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Crystalline Powder
pka 3.47(at 20℃)
color  Slightly brown to beige
Water Solubility  Soluble in water, methanol, chloroform.
Merck  14,7370
BRN  109240
CAS DataBase Reference 253-52-1(CAS DataBase Reference)
NIST Chemistry Reference Phthalazine(253-52-1)
EPA Substance Registry System Phthalazine (253-52-1)

Safety information for Phthalazine

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Phthalazine

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