Phthalazine
Synonym(s):β-Phenodiazine;2,3-Benzodiazine;Phthalazine
- CAS NO.：253-52-1
- Empirical Formula: C8H6N2
- Molecular Weight: 130.15
- MDL number: MFCD00006908
- EINECS: 205-963-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is Phthalazine?
Chemical properties
SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER
The Uses of Phthalazine
Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors.
The Uses of Phthalazine
Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia.
Definition
ChEBI: Phthalazine is an azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. It is a mancude organic heterobicyclic parent, a member of phthalazines, an azaarene and an ortho-fused heteroarene.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219
Purification Methods
Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.]
Properties of Phthalazine
| Melting point: | 89-92 °C(lit.) |
| Boiling point: | 189 °C29 mm Hg(lit.) |
| Density | 1.1509 (rough estimate) |
| refractive index | 1.6231 (estimate) |
| Flash point: | 178-180°C/15mm |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 3.47(at 20℃) |
| color | Slightly brown to beige |
| Water Solubility | Soluble in water, methanol, chloroform. |
| Merck | 14,7370 |
| BRN | 109240 |
| CAS DataBase Reference | 253-52-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Phthalazine(253-52-1) |
| EPA Substance Registry System | Phthalazine (253-52-1) |
Safety information for Phthalazine
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H341:Germ cell mutagenicity H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Phthalazine
Phthalazine manufacturer
Mahrshee Laboratories Pvt Ltd
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