Phenylbutazone
Synonym(s):4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione;Phenylbutazone
- CAS NO.:50-33-9
- Empirical Formula: C19H20N2O2
- Molecular Weight: 308.37
- MDL number: MFCD00005500
- EINECS: 200-029-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 14:24:42
What is Phenylbutazone?
Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
The Uses of Phenylbutazone
Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.
Indications
For the treatment of backache and ankylosing spondylitis
Background
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
What are the applications of Application
Phenylbutazone is an inhibitor of Cox
Pharmacokinetics
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Metabolism
Not Available
Properties of Phenylbutazone
Melting point: | 106-108 °C (lit.) |
Boiling point: | 448.76°C (rough estimate) |
Density | 1.1591 (rough estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions. |
form | Powder |
color | White to almost white |
Water Solubility | <0.1 g/100 mL at 23.5 ºC |
Safety information for Phenylbutazone
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phenylbutazone
InChIKey | VYMDGNCVAMGZFE-UHFFFAOYSA-N |
Abamectin manufacturer
Reine Lifescience
Heer Pharma Pvt Ltd
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