Penconazole

CAS NO.：66246-88-6
Empirical Formula: C13H15Cl2N3
Molecular Weight: 284.18
MDL number: MFCD00078737
EINECS: 266-275-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-26 15:15:06

What is Penconazole?

The Uses of Penconazole

Penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.

The Uses of Penconazole

Penconazole is used for the control of powdery mildew, pome fruit scab and other pathogenic Ascomycetes, Basidiomycetes and Deuteromycetes on vines, cucurbits, pome fruit, stone fruit, ornamentals, hops, tobacco and vegetables.

Definition

ChEBI: 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole is a member of the classof triazoles that is 1,2,4-triazole substituted at position 1 by a 2-(2,4-dichlorophenyl)pentyl group. It is a dichlorobenzene and a member of triazoles.

Agricultural Uses

Fungicide: Penconazole is a systemic fungicide used to control powdery mildew. It is used on apples and grapes and other fruits, hops, tobacco, ornamentals and on vegetables. Not currently registered in the U.S. Reported to be used in most European countries. Currently, there are more than 30 global suppliers.

Trade name

AWARD®; CGA-71818®; ONMEX®; TOPAS®; TOPAS-C®; TOPAS-MZ®; TOPAZ®; TOPAZE®; TOPAZE-C®; TOPENCO 100EC®

Safety Profile

Moderately toxic by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx and Clí.

Metabolic pathway

Penconazole is metabolised in plants by hydroxylation of the propyl side chain and conjugation or metabolism to triazolylalanine and triazolylacetic acid. It is quite persistent in soils but degradation by sunlight requires only a few days. It is eliminated rapidly from mammals.

Degradation

Penconazole (1) is stable to hydrolysis at pH 1-13 and at temperatures up to 350 °C. It is degraded in sunlight with a DT₅₀ of 4 days in natural sunlight. Its photochemical reactions have been studied. On irradiation with light of wavelengths greater than 280 nm (high-pressure mercury lamp with filter), the major reaction was the formation of a cyclised product (2) (Scheme 1). Irradiation under the same conditions in isopropanol gave mainly 2 and 3 (a dechlorinated product). After 8 hours, yields were 29.8% of 2 and 12.3% of 3 respectively. The product 3 alone photodegraded only slowly but 2 was completely photolysed within 3 hours to further products, indicating its role as an intermediate in the photolytic pathways (Schwack and Hartmann, 1992, 1994). In the presence of isopropanol, photodehalogenation of 3 to 4 competed with substitution of a solvent molecule to give a low yield (

Properties of Penconazole

Melting point:	58.5 °C
Boiling point:	436.06°C (rough estimate)
Density	1.2556 (rough estimate)
vapor pressure	3.7 x l0^-4 Pa (25 °C)
refractive index	1.6300 (estimate)
Flash point:	100 °C
storage temp.	0-6°C
solubility	DMSO: 100 mg/mL (351.89 mM)
pka	2.80±0.10(Predicted)
form	Solid
form	neat
Water Solubility	73 mg l^-1 (25 °C)
color	White
BRN	541488
CAS DataBase Reference	66246-88-6(CAS DataBase Reference)
EPA Substance Registry System	Penconazole (66246-88-6)

Safety information for Penconazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P308+P313:IF exposed or concerned: Get medical advice/attention.