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HomeProduct name listPasiniazid

Pasiniazid

Synonym(s):Isonicotinic acid hydrazide p-aminosalicylate salt

  • CAS NO.:2066-89-9
  • Empirical Formula: C13H14N4O4
  • Molecular Weight: 290.27
  • MDL number: MFCD00079376
  • EINECS: 218-183-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Pasiniazid Structural

What is Pasiniazid?

Originator

Pasinazid, Yick-Vic Chemicals

The Uses of Pasiniazid

Pasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM).

The Uses of Pasiniazid

antibacterial (tuberculostatic)

Manufacturing Process

10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative

Therapeutic Function

Antitubercular

Properties of Pasiniazid

Melting point: 142-144°
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Water
form  neat
form  Solid
color  Light yellow to khaki

Safety information for Pasiniazid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pasiniazid

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