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HomeProduct name listOxyresveratrol

Oxyresveratrol

Synonym(s):(E)-2,3′,4,5′-Stilbenetetrol;2,3′,4,5′-Tetrahydroxy-trans-stilbene;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Oxyresveratrol

  • CAS NO.:29700-22-9
  • Empirical Formula: C14H12O4
  • Molecular Weight: 244.24
  • MDL number: MFCD11974969
  • EINECS: 608-401-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:09:03
Oxyresveratrol Structural

What is Oxyresveratrol?

Description

Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects.

Chemical properties

White powder

The Uses of Oxyresveratrol

Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent.

Definition

ChEBI: Oxyresveratrol is a stilbenoid.

Biological Activity

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM)
In vitro:
1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.
2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity.
3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.
In vivo:
1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.
2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats.

Solubility in organics

Oxyresveratrol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of oxyresveratrol in these solvents is approximately 50 mg/ml.

Properties of Oxyresveratrol

Melting point: 201-202.5 °C
Boiling point: 523.8±30.0 °C(Predicted)
Density  1.468±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Ethyl Acetate (Slightly), Methanol
form  Solid
pka 9.14±0.10(Predicted)
color  Pale Yellow to Pale Beige
CAS DataBase Reference 29700-22-9(CAS DataBase Reference)

Safety information for Oxyresveratrol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Oxyresveratrol

InChIKey PDHAOJSHSJQANO-OWOJBTEDSA-N

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