Oxyresveratrol
Synonym(s):(E)-2,3′,4,5′-Stilbenetetrol;2,3′,4,5′-Tetrahydroxy-trans-stilbene;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Oxyresveratrol
- CAS NO.:29700-22-9
- Empirical Formula: C14H12O4
- Molecular Weight: 244.24
- MDL number: MFCD11974969
- EINECS: 608-401-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is Oxyresveratrol?
Description
Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects.
Chemical properties
White powder
The Uses of Oxyresveratrol
Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent.
Definition
ChEBI: Oxyresveratrol is a stilbenoid.
Biological Activity
Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM)
In vitro:
1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.
2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity.
3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.
In vivo:
1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.
2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats.
Solubility in organics
Oxyresveratrol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of oxyresveratrol in these solvents is approximately 50 mg/ml.
Properties of Oxyresveratrol
Melting point: | 201-202.5 °C |
Boiling point: | 523.8±30.0 °C(Predicted) |
Density | 1.468±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Ethyl Acetate (Slightly), Methanol |
form | Solid |
pka | 9.14±0.10(Predicted) |
color | Pale Yellow to Pale Beige |
CAS DataBase Reference | 29700-22-9(CAS DataBase Reference) |
Safety information for Oxyresveratrol
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for Oxyresveratrol
InChIKey | PDHAOJSHSJQANO-OWOJBTEDSA-N |
Abamectin manufacturer
Sami Sabinsa Group Limited (formerly Sami Labs Limited)
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