rhapontigenin
- CAS NO.:500-65-2
- Empirical Formula: C15H14O4
- Molecular Weight: 258.27
- MDL number: MFCD00017718
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 13:42:50
What is rhapontigenin?
Description
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-
The Uses of rhapontigenin
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical]
The Uses of rhapontigenin
Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.
What are the applications of Application
ARhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1, with antioxidant and anti-cancer activity.
Definition
ChEBI: Rhapontigenin is a stilbenoid.
References
[1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.
[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.
[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86.
Properties of rhapontigenin
Melting point: | 189.0 to 193.0 °C |
Boiling point: | 503.6±38.0 °C(Predicted) |
Density | 1.345±0.06 g/cm3(Predicted) |
storage temp. | 4°C, protect from light |
solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
pka | 9.17±0.10(Predicted) |
form | powder to crystal |
color | White to Light yellow |
CAS DataBase Reference | 500-65-2 |
Safety information for rhapontigenin
Computed Descriptors for rhapontigenin
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