rhapontigenin
- CAS NO.:500-65-2
- Empirical Formula: C15H14O4
- Molecular Weight: 258.27
- MDL number: MFCD00017718
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-12 15:22:20
What is rhapontigenin?
Description
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-
The Uses of rhapontigenin
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical]
The Uses of rhapontigenin
Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.
What are the applications of Application
ARhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1, with antioxidant and anti-cancer activity.
Definition
ChEBI: Rhapontigenin is a stilbenoid.
References
[1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.
[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.
[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86.
Properties of rhapontigenin
Melting point: | 189.0 to 193.0 °C |
Boiling point: | 503.6±38.0 °C(Predicted) |
Density | 1.345±0.06 g/cm3(Predicted) |
storage temp. | 4°C, protect from light |
solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
pka | 9.17±0.10(Predicted) |
form | powder to crystal |
color | White to Light yellow |
CAS DataBase Reference | 500-65-2 |
Safety information for rhapontigenin
Computed Descriptors for rhapontigenin
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR AMLODIPINE SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE 5-Fluoro-2-iodo-3-methylaniline Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 3-Bromo-2-hydroxybenzeneacetic acid 5-Iodo-3-methyl-2-nitropyridine 1-(3-Chloro-2-hydroxyphenyl)-2-propanoneRelated products of tetrahydrofuran
You may like
-
Rhapontigenin CAS 500-65-2View Details
500-65-2 -
Rhapontigenin 98% CAS 500-65-2View Details
500-65-2 -
446292-08-6 (S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione 99View Details
446292-08-6 -
Iminostilbene 256-96-2 98View Details
256-96-2 -
147403-52-9 > 99View Details
147403-52-9 -
5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride 120013-39-0 > 99.0View Details
120013-39-0 -
718635-93-9 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one >99%View Details
718635-93-9 -
147403-65-4 > 99View Details
147403-65-4