OXOTREMORINE
- CAS NO.:70-22-4
- Empirical Formula: C12H18N2O
- Molecular Weight: 206.28
- MDL number: MFCD00003200
- EINECS: 200-728-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is OXOTREMORINE?
Definition
ChEBI: Oxotremorine is a N-alkylpyrrolidine.
General Description
Oxotremorine [1-(-pyrrolidono)-4-pyrrolidino-2-butyne] has been regarded as a CNS muscarinicstimulant. Its action on the brain produces tremors inexperimental animals. It increases ACh brain levels in ratsup to 40% and has been studied as a drug in the treatment ofAlzheimer disease. Although earlier studies suggested thatthis approach of elevating levels of ACh to treat Alzheimerdisease is useful, this belief was highly disputed by manyresearchers.
Clinical Use
Nevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
Properties of OXOTREMORINE
Melting point: | <25 °C |
Boiling point: | 124 °C0.1 mm Hg(lit.) |
Density | 1 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 113 °C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | liquid |
pka | 8.29±0.20(Predicted) |
color | clear, light yellow |
Merck | 13,7020 |
Safety information for OXOTREMORINE
Computed Descriptors for OXOTREMORINE
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin I 2,2-diethoxyethanethioamide Tubulysin G 4-(Benzyloxy)-3-bromophenylacetic Acid Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-Aminocyclobutanone hydrochloride 2,2-Difluoropropanol 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (R)-1-Aminoindan Hydrochloride 4-(2-fluoro-4- nitrophenyl) thiomorpholine Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
109113-72-6 2-(Chloromethyl)-4-methylquinazoline (2-CMQ) 98%View Details
109113-72-6 -
Hydrogen Gas 98%View Details
-
590-17-0 Bromoacetonitrile 98%View Details
590-17-0 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8