Diethylacetamide

Synonym(s):Acetic acid diethylamide;N,N-Diethylacetamide

CAS NO.：685-91-6
Empirical Formula: C6H13NO
Molecular Weight: 115.17
MDL number: MFCD00009047
EINECS: 211-685-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is Diethylacetamide?

Chemical properties

clear colorless liquid

The Uses of Diethylacetamide

N,N-Diethylacetamide was used to investigate the spectroscopic properties ofN,N-diethyl-2-[(4-substituted)phenylsulfinyl] acetamides. It is commonly used as drug solvent.

Synthesis Reference(s)

Chemistry Letters, 18, p. 1983, 1989
The Journal of Organic Chemistry, 59, p. 4035, 1994 DOI: 10.1021/jo00094a004

General Description

N,N-Diethylacetamide is commonly used as drug solvent.

Hazard

Toxic by ingestion.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Flammable when exposed to heat or flame. To fight fire, use foam, mist, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dissolve the amide in cyclohexane, shake with anhydrous BaO and then filter. The procedure is repeated three times, and the cyclohexane is distilled off at atmospheric pressure. The crude amide is also fractionally distilled three times from anhydrous BaO. [Beilstein 4 III 349.]

Properties of Diethylacetamide

Melting point:	<20 °C
Boiling point:	182-186 °C (lit.)
Density	0.925 g/mL at 25 °C (lit.)
vapor pressure	1.2 hPa (25 °C)
refractive index	n20/D 1.440(lit.)
Flash point:	159 °F
storage temp.	Store below +30°C.
solubility	53.5g/l
form	clear liquid
pka	-0.41±0.70(Predicted)
color	Colorless to Almost colorless
Water Solubility	Soluble in water.
BRN	1209428
Dielectric constant	31.329999999999998
CAS DataBase Reference	685-91-6(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, N,N-diethyl-(685-91-6)
EPA Substance Registry System	N,N-Diethylacetamide (685-91-6)

Safety information for Diethylacetamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.