Obatoclax mesilate
- CAS NO.:803712-79-0
- Empirical Formula: C20H19N3O.CH4O3S
- Molecular Weight: 413.49
- MDL number: MFCD18074508
- EINECS: 804-325-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is Obatoclax mesilate?
Description
Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.
Chemical properties
Red powder
The Uses of Obatoclax mesilate
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
The Uses of Obatoclax mesilate
Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.
What are the applications of Application
Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic
storage
Store at -20°C
References
1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409
Properties of Obatoclax mesilate
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 5 mg/ml). |
form | solid |
color | Purple |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for Obatoclax mesilate
Computed Descriptors for Obatoclax mesilate
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