NUTLIN-3
Synonym(s):(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;MDM2 Inhibitor IV
- CAS NO.:548472-68-0
- Empirical Formula: C30H30Cl2N4O4
- Molecular Weight: 581.49
- MDL number: MFCD07784509
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is NUTLIN-3?
Description
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
The Uses of NUTLIN-3
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
What are the applications of Application
Nutlin-3 is an apoptosis inducer and disruptor of MDM2-p53 interaction, inhibiting with a IC50 of 0.09 μM.
Definition
ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.
Biochem/physiol Actions
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.
storage
Store at -20°C
References
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
Properties of NUTLIN-3
Melting point: | >132oC (dec.) |
Density | 1.36±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: 20 mg/mL, soluble |
pka | 14.35±0.20(Predicted) |
form | solid |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Safety information for NUTLIN-3
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NUTLIN-3
InChIKey | BDUHCSBCVGXTJM-UHFFFAOYSA-N |
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