Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listNUTLIN-3

NUTLIN-3

Synonym(s):(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;MDM2 Inhibitor IV

  • CAS NO.:548472-68-0
  • Empirical Formula: C30H30Cl2N4O4
  • Molecular Weight: 581.49
  • MDL number: MFCD07784509
  • EINECS: 200-258-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
NUTLIN-3 Structural

What is NUTLIN-3?

Description

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.

The Uses of NUTLIN-3

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.

What are the applications of Application

Nutlin-3 is an apoptosis inducer and disruptor of MDM2-p53 interaction, inhibiting with a IC50 of 0.09 μM.

Definition

ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.

Biochem/physiol Actions

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.

storage

Store at -20°C

References

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859

Properties of NUTLIN-3

Melting point: >132oC (dec.)
Density  1.36±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: 20 mg/mL, soluble
pka 14.35±0.20(Predicted)
form  solid
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety information for NUTLIN-3

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for NUTLIN-3

InChIKey BDUHCSBCVGXTJM-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.