NS1643
- CAS NO.：448895-37-2
- Empirical Formula: C15H10F6N2O3
- Molecular Weight: 380.24
- MDL number: MFCD08705418
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is NS1643?
The Uses of NS1643
NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator.
What are the applications of Application
NS 1643 is an antiarrhythmic activator of hERG K+ channels
Biological Activity
Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro .
storage
+4°C
Properties of NS1643
| Boiling point: | 342.3±42.0 °C(Predicted) |
| Density | 1.626±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 6.84±0.13(Predicted) |
| form | solid |
| color | white to off-white |
Safety information for NS1643
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NS1643
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin G Tubulysin E Tubulysin M (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Methyl 4-amino-3-(4-phenylpiperazin-1-yl)benzoate 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate Diethyl 2,5-di(furan-2-yl)terephthalate 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4R,12aR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1`,2`;4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 4-bromopyrimidin-2-amine 3-bromo-5-fluorobenzaldehydeRelated products of tetrahydrofuran
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