N,N-Dibenzylhydroxylamine
- CAS NO.:621-07-8
- Empirical Formula: C14H15NO
- Molecular Weight: 213.27
- MDL number: MFCD00004772
- EINECS: 210-667-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is N,N-Dibenzylhydroxylamine?
Chemical properties
white to slightly yellow adhering crystalline
The Uses of N,N-Dibenzylhydroxylamine
N,N-Dibenzylhydroxylamine, upon oxidation, yields N-benzyl-α-phenylnitrone, which can undergo cycloaddition reaction with suitable dipolarophiles. It can be used to synthesize N,N,O-trisubstituted hydroxylamines and arylamines.
Preparation
A mixture of 14 gm (0.202 mole) of hydroxylamine hydrochloride and 50 gm (0.395 mole) of benzyl chloride in 200 ml of 70% ethanol is treated with 60 gm of crystalline sodium carbonate. The mixture is heated under a reflux condenser for 2 hr, cooled to room temperature, filtered, and the solids discarded. The filtrate is treated with sufficient ice water to cause precipitation of A^N-dibenzylhydroxylamine. The reaction mixture is then thoroughly cooled in a freezing mixture to permit complete precipitation of product to take place. The yield, upon filtration, is 26 gm (61.5%), m.p. 123°C. A similar preparation has recently been reported [13a].
Properties of N,N-Dibenzylhydroxylamine
Melting point: | 125-128 °C (lit.) |
Boiling point: | 353.27°C (rough estimate) |
Density | 1.0439 (rough estimate) |
refractive index | 1.5300 (estimate) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
Water Solubility | Insoluble in water |
form | powder to crystal |
pka | 13.19±0.69(Predicted) |
color | White to Almost white |
BRN | 978234 |
CAS DataBase Reference | 621-07-8(CAS DataBase Reference) |
NIST Chemistry Reference | Hydroxylamine, n,n-dibenzyl-,(621-07-8) |
EPA Substance Registry System | Benzenemethanamine, N-hydroxy-N-(phenylmethyl)- (621-07-8) |
Safety information for N,N-Dibenzylhydroxylamine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N-Dibenzylhydroxylamine
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