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HomeProduct name listDibenzylideneacetone

Dibenzylideneacetone

Synonym(s):trans,trans-1,5-Diphenyl-1,4-pentadien-3-one;1,5-Diphenyl-1,4-pentadien-3-one

  • CAS NO.:538-58-9
  • Empirical Formula: C17H14O
  • Molecular Weight: 234.29
  • MDL number: MFCD00004790
  • EINECS: 208-697-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-08 20:25:11
Dibenzylideneacetone Structural

What is Dibenzylideneacetone?

Chemical properties

trans,trans-Dibenzylideneacetone is a crystalline solid, melting point 110-111℃; cis-trans is a light yellow needle crystal, melting point 60℃; cis-cis is a yellow oily liquid, boiling point 130℃ (2.7Pa). Soluble in ethanol, acetone, chloroform, insoluble in water.

The Uses of Dibenzylideneacetone

Dibenzylideneacetone is used as a ligand to prepare palladium catalysts, which are widely used in catalytic hydrogenation, coupling, carbonylation, alkyne ring trimerization, etc.

Preparation

Dibenzylideneacetone is obtained by the reaction of benzaldehyde and acetone. The reaction was carried out in aqueous ethanol solution at a reaction temperature of 20-25°C with a yield of 78%.

Synthesis Reference(s)

Chemistry Letters, 9, p. 51, 1980
The Journal of Organic Chemistry, 45, p. 3840, 1980 DOI: 10.1021/jo01307a022
Organic Syntheses, Coll. Vol. 2, p. 167, 1943

Biological Activity

Dibenzylideneacetone (DBA) showed inhibitory activity against Botrytis cinerea Chitinase with an IC50 of 13.10 μg/mL. The MIC of DBA against B. cinerea was 32 μg/mL, and the EC50 values for inhibition of hyphae growth and spore germination were 16.29 and 14.64 μg/mL, respectively. DBA was able to significantly extend the shelf life of cherry tomato shelf life and is a promising antifungal agent for fruit preservation[1].

Purification Methods

Crystallise the ketone from hot ethyl acetate (2.5mL/g) or EtOH. [Beilstein 7 IV 1747.]

References

[1] XIAODI NIU; Chenyang W; Ziyou Wang, HONGSU WANG*. Dibenzylideneacetone Overcomes Botrytis cinerea Infection in Cherry Tomatoes by Inhibiting Chitinase Activity[J]. Journal of Agricultural and Food Chemistry, 2023. DOI:10.1021/acs.jafc.3c05695.

Properties of Dibenzylideneacetone

Melting point: 107-113 °C
Boiling point: 336.62°C (rough estimate)
Density  1.0477 (rough estimate)
refractive index  1.5000 (estimate)
storage temp.  Sealed in dry,Room Temperature
form  solid
color  yellow
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
CAS DataBase Reference 538-58-9(CAS DataBase Reference)
EPA Substance Registry System 1,4-Pentadien-3-one, 1,5-diphenyl- (538-58-9)

Safety information for Dibenzylideneacetone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Dibenzylideneacetone

InChIKey WMKGGPCROCCUDY-UHFFFAOYSA-N

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